Vito Guagnano: search on Z-Library

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1

Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

Furet, Pascal, Masuya, Keiichi, Kallen, Joerg, Stachyra-Valat, Thérèse, Ruetz, Stephan, Guagnano, Vito, Holzer, Philipp, Mah, Robert, Stutz, Stefan, Vaupel, Andrea, Chène, Patrick, Jeay, Sébastien, Sc

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 816 KB

english, 2016

2

Aromatic Interactions with Phenylalanine 691 and Cysteine 828: A Concept for FMS-like Tyrosine Kinase-3 Inhibition. Application to the Discovery of a New Class of Potential Antileukemia Agents

Furet, Pascal, Bold, Guido, Meyer, Thomas, Roesel, Johannes, Guagnano, Vito

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 193 KB

english, 2006

3

Corrigendum to “Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation” [Bioorg. Med. Chem. Lett. 23 (2013) 3741–3748]

Furet, Pascal, Guagnano, Vito, Fairhurst, Robin A., Imbach-Weese, Patricia, Bruce, Ian, Knapp, Mark, Fritsch, Christine, Blasco, Francesca, Blanz, Joachim, Aichholz, Reiner, Hamon, Jacques, Fabbro, Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 233 KB

english, 2013

4

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

Furet, Pascal, Guagnano, Vito, Fairhurst, Robin A., Imbach-Weese, Patricia, Bruce, Ian, Knapp, Mark, Fritsch, Christine, Blasco, Francesca, Blanz, Joachim, Aichholz, Reiner, Hamon, Jacques, Fabbro, Do

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 2.86 MB

english, 2013

5

Reactivity of 3-nitro-5,6-dihydro-4H-pyran with organoalanes: Preparation of (E)-α, β-ethylenic aldehydes.

Rita Menicagli, Vito Guagnano, Corrado Malanga

Journal:

Year:

1994

Language:

english

File:

PDF, 481 KB

english, 1994

6

ChemInform Abstract: Synthesis and Biological Evaluation of Highly Potent Analogues of Epothilones B and D.

Karl-Heinz Altmann, Guido Bold, Giorgio Caravatti, Andreas Floersheimer, Vito Guagnano, Markus Wartmann

Journal:

Year:

2001

File:

PDF, 35 KB

2001

7

Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors

Fairhurst, Robin A., Caravatti, Giorgio, Guagnano, Vito, Aichholz, Reiner, Blanz, Joachim, Blasco, Francesca, Wipfli, Peter, Fritsch, Christine, Maira, Sauveur-Michel, Schnell, Christian, Seiler, Fran

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.11 MB

english, 2016

8

Structural states of Hdm2 and HdmX: X‐ray elucidation of adaptations and binding interactions for different chemical compound classes

Kallen, Joerg, Izaac, Aude, Chau, Suzanne, Wirth, Emmanuelle, Schoepfer, Joseph, Mah, Robert, Schlapbach, Achim, Stutz, Stefan, Vaupel, Andrea, Guagnano, Vito, Masuya, Keiichi, Stachyra, Therese-Marie

Journal:

Year:

2019

Language:

english

File:

PDF, 3.02 MB

english, 2019

9

Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions. 6. The Bridged Mode

Denmark, Scott E., Stolle, Andreas, Dixon, Julie A., Guagnano, Vito

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 301 KB

english, 1995

10

Entry into a new class of protein kinase inhibitors by pseudo ring design

Pascal Furet, Giorgio Caravatti, Vito Guagnano, Marc Lang, Thomas Meyer, Joseph Schoepfer

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 219 KB

english, 2008

11

Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions of Nitroalkenes. 15. The Bridged Mode (α-Tether)

Denmark, Scott E., Guagnano, Vito, Dixon, Julie A., Stolle, Andreas

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 851 KB

english, 1997

12

Synthesis and biological evaluation of highly potent analogues of epothilones B and D

Karl-Heinz Altmann, Guido Bold, Giorgio Caravatti, Andreas Flörsheimer, Vito Guagnano, Markus Wartmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 194 KB

english, 2000

13

Regioselective Ni(II)-assisted alkylation of 2-methoxy-5,6-dihydro-2H-pyran: a new route to 2-n-alkyl-5,6-dihydro-2H-pyrans

Vito Guagnano, Luciano Lardicci, Corrado Malanga, Rita Menicagli

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 130 KB

english, 1998

14

In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Vaupel, Andrea, Holzer, Philipp, Ferretti, Stephane, Guagnano, Vito, Kallen, Joerg, Mah, Robert, Masuya, Keiichi, Ruetz, Stephan, Rynn, Caroline, Schlapbach, Achim, Stachyra, Thérèse, Stutz, Stefan, T

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 1.08 MB

english, 2018

15

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

Guagnano, Vito, Furet, Pascal, Spanka, Carsten, Bordas, Vincent, Le Douget, Mickaël, Stamm, Christelle, Brueggen, Josef, Jensen, Michael R., Schnell, Christian, Schmid, Herbert, Wartmann, Markus, Berg

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.13 MB

english, 2011

16

Non-Covalent Inhibitors of the 20S Proteasome

García-Echeverría, Carlos, Imbach, Patricia, Roesel, Johannes, Fuerst, Peter, Lang, Marc, Guagnano, Vito, Noorani, Maria, Zimmermann, Johann, Furet, Pascal

Journal:

CHIMIA International Journal for Chemistry

Year:

2003

Language:

english

File:

PDF, 83 KB

english, 2003

17

Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets

Wöhrle, Simon, Henninger, Christine, Bonny, Olivier, Thuery, Anne, Beluch, Noemie, Hynes, Nancy E, Guagnano, Vito, Sellers, William R, Hofmann, Francesco, Kneissel, Michaela, Graus Porta, Diana

Journal:

Journal of Bone and Mineral Research

Year:

2013

Language:

english

File:

PDF, 1.64 MB

english, 2013

18

Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors

Fairhurst, Robin A., Marsilje, Thomas H., Stutz, Stefan, Boos, Andreas, Niklaus, Michel, Chen, Bei, Jiang, Songchun, Lu, Wenshuo, Furet, Pascal, McCarthy, Clive, Stauffer, Frédéric, Guagnano, Vito, Va

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 1.43 MB

english, 2016

19

Entry into a New Class of Potent Proteasome Inhibitors Having High Antiproliferative Activity by Structure-Based Design

Furet, Pascal, Imbach, Patricia, Noorani, Maria, Koeppler, Juergen, Laumen, Kurt, Lang, Marc, Guagnano, Vito, Fuerst, Peter, Roesel, Johannes, Zimmermann, Johann, García-Echeverría, Carlos

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 203 KB

english, 2004

20

Studies on the reduction and hydrolysis of nitroso acetals

Denmark, Scott E, Guagnano, Vito, Vaugeois, Jean

Journal:

Canadian Journal of Chemistry

Year:

2001

Language:

english

File:

PDF, 364 KB

english, 2001

21

Novel β-lactam derivatives: Potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome

Patricia Imbach, Marc Lang, Carlos García-Echeverría, Vito Guagnano, Maria Noorani, Johannes Roesel, Francis Bitsch, Grety Rihs, Pascal Furet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 334 KB

english, 2007

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